How Sophora is effective for various diseases is listed in repertory format. Although this herb is generally not consumed as a dietary supplement in the West, recent lab studies indicate that it has antitumor properties and patients are using it as a natural cancer treatment. Kim HA, You HK, Shin HS, Kim YC, Kang TH, Yu HH. In animal models, the antiviral properties of sophoridine, an alkaloid constituent, appear to be mediated via upregulation of IL-10 and IFN-gamma cytokines (11). The certainty of the evidence on the use of Radix Sophorae flavescentis in people with chronic HBV in terms of its beneficial or harmful effects on death, health-related quality of life, risk of dying due to HBV infection, and serious side effects cannot be determined as none of the trials reported patient-relevant outcomes. Names of Sophora in various languages of the world are also given. ASSF can be applied and get good effects. In China, active ingredients in Sophora flavescens like matrine (MT), oxymatrine (OMT), other Sophora flavescens alkaloids and Compound Kushen Injection (CKI) are extensively used for multiple malignant tumors. List of various diseases cured by Sophora. Names of Sophora Flavescens in various languages of the world are also given. ARTICLE INFO Keywords: Oxymatrine from Sophora flavescens Chronic constrictive injury NR2B p-ERK p-CREB Neuropathic pain ABSTRACT Purpose: In this study we investigated a ntinociceptive effects of oxymatrine through regulation of NR2B-containing NMDA receptor-ERK/CREB signaling in a chronic neuropathic pain model induced by chronic constrictive injury (CCI) of the sciatic … Most reported antineoplastic effects of S.flavescens are due to the proapoptotic activity of matrine, the main alkaloid constituent. A herbal record lists the following adverse effects of Ku shen: salivation, abnormal gait, dyspnea, tachycardia [ 85 ]. Sophora also contain these valuable constituents. Evaluation of the estrogenic activity of Leguminosae plants. Sophora Flavescens (Ku Shen) is a medicinal herb from China that appears to possess mostly anti-cancer properties. Uses, Benefits, Cures, Side Effects, Nutrients in Sophora Flavescens. Excessive use of it may cause poisoning reactions such as dizziness, headache, restlessness, numbness of the limbs, increased urination, shortness of breath, or rapid heartbeat. Figure 1 . Matrine-induced apoptosis in leukemia U937 cells: involvement of caspases activation and MAPK-independent pathways. Sophora flavescens side effects and contraindications. References Matrine induces apoptosis in gastric carcinoma cells via alteration of Fas/FasL and activation of caspase-3. View chapter … Sophora flavescens is a deciduous shrub related to peas. The flavonoids sophoraflavonone G and kurarinone may be responsible for antioxidant effects, which are mediated through free-radical scavenging (4). Effects of aqueous extract of Sophora flavescens on the expression of cell cycle regulatory proteins in human oral mucosal fibroblasts. The present study was to investigate the anti-cancer effect of oxymatrine on human pancreatic cancer PANC-1 cells, and its possible molecular mechanism. Another person experienced fatigue and headache. It might cause side effects such as a bitter mouth, stomach discomfort, and drowsiness. Matrine, an alkaloid present in Sophora flavescens, demonstrated antitumor effects against liver (10) (18), breast (19), pancreatic  (20), myeloma (21) and gastric (22) (23) cancer cell lines. According to Niu Kuizhi (5), “Sophora has little side effect. Peony has been used safely for up to 6 … Anti-inflammatory effects of Sophoraflavonone G are attributed to inhibition of prostaglandin E2 formation via COX-2 downregulation (13). Effects of sophoraflavanone G, a prenylated flavonoid from, Pharmacokinetic study of matrine, oxymatrine and oxysophocarpine in rat plasma after oral administration of. In larger doses, nervous system stimulation with muscle spasm and seizures can occur. Ku shen is a Chinese herbal remedy made from the root of S. falves-cens. (Leguminosae) (Kim et al., 2003), Glycyrrhiza uralensis Fisch. Both sophora flavescens seeds and roots are considered toxic (poisonous). Sophora flavescens or Ku Shen, which in Chinese means “bitter root,” is an herb used in Traditional medicine to treat a wide variety of symptoms, with purported effects on the liver, intestinal tract, and skin. It may cause Anorexia. Patients with hormone-sensitive cancers should avoid taking, © 2020 Memorial Sloan Kettering Cancer Center, Gerstner Sloan Kettering Graduate School of Biomedical Sciences, Integrative Medicine at Home Membership Program. Uses, Benefits, Cures, Side Effects, Nutrients in Sophora. In human hepatocellular carcinoma cells, matrine inhibits matrix metalloproteinase-9 (MMP-9) by downregulating the NF-kappa B pathway (18). A lot of studies showed that some chemical composition in Radix Sophora flavescens was able to inhibit tumor cells in vitro (Zhang et al., 2012; Pu et al., 2013). New approach in asthma treatment using excitatory modulator. It is classified as a poisonous plant in the database of China Botanical Illustration. Since prednisone causes diabetes, spinal fractures, weight gain and other severe side effects… (2S)-2’-Methoxykurarinone isolated from S. flavescens root inhibits osteoclast differentiation and bone resorption via receptor activator of nuclear factor-κB ligand (RANKL)-induced mitogen-activated protein kinases (MAPKs) and c-Fos-NFATc1 signaling pathways (29). From radiation therapy to clinical trials to check-ins with your doctor, your care is made as convenient as possible. Find treatment reviews for Sophora flavescens root from other patients. Avoid in case of Spleen and Stomach deficiency due to Cold. However, human data are lacking. S. flavescens Extract Increases Axons at the Lesion Site and Improves Motor Dysfunction in SCI Mice. Adverse effects. It may also inhibit the 5-Alpha Reductase enzyme and PDE5 potently, promoting hair growth and erectogenesis. Use of this Web site does not create an expressed or implied physician-patient relationship. Antiviral effects of sophoridine against coxsackievirus B3 and its pharmacokinetics in rats. 苦參 Flavescent sophora root (Kushen) Pharmaceutical Name: Radix Sophorae flavescentis Botanical Name: Sophora flavescens Ait. List of various diseases cured by Sophora Flavescens. When used in excessive dosage, it might give rise to some symptoms of the digestive tract, such as malaise of stomach, nausea, vomiting, and constipation; occasionally, dizziness, alopecia, and rash. In one study, one person experienced heartburn, shaking hands, sexual dysfunction, and thyroid dysfunction. Hypoxia is a very common phenomenon in solid tumors and leads to aggressive phenotype and treatment failure. Learn from their experiences about effectiveness, side effects and cost Health-related information changes frequently and therefore information contained on this Web site may be outdated, incomplete or incorrect. Common Name: Flavescent sophora root Source of Earliest Record: Shennong Bencao Jing Part Used: The roots are dug in spring or autumn. In larger doses, nervous system stimulation with muscle spasm and seizures can occur. Also at very high dosage levels, there is some evidence of immunosuppression from animal and in vitro studies. Donate today. And Qing luo yin, a Chinese herbal remedy for rheumatoid arthritis, is a combination of extracts of Dioscorea hypoglauca, Phellodendron amurense, Sinomenium acutum, and S. flavescens. The adverse effects are related to dosage. Your generosity makes this possible. Any questions regarding your own health should be addressed to your own physician or other healthcare provider. And Qing luo yin, a Chinese herbal remedy for rheumatoid arthritis, is a combination of extracts of Dioscorea hypoglauca, Phellodendron amurense, Sinomenium acutum, and S. flavescens. This Web site is not to be used as a substitute for medical advice, diagnosis or treatment of any health condition or problem. Therapeutic effects of matrine on primary and metastatic breast cancer. Identification and characterization of antioxidants from. Antibacterial activity of sophoraflavanone G isolated from the roots of. After the fibrous roots have been removed, the roots are cleaned, cut into slices and dried in the sun. However, serious side effects of chemotherapy has limited treatment success [2,3]. Matrine inhibits matrix metalloproteinase-9 expression and invasion of human hepatocellular carcinoma cells. Rated 5 out of 5 by conniecam from Wow! Memorial Sloan Kettering Cancer Center makes no warranties nor express or implied representations whatsoever regarding the accuracy, completeness, timeliness, comparative or controversial nature, or usefulness of any information contained or referenced on this Web site. However, large-scale clinical studies are needed to confirm these effects in humans.Sophora flavescens acts as a phytoestrogen (24) (25) (26). Statements made about products have not been evaluated by the Food and Drug Administration. Sophora falvescens (Ku shen) contains a variety of matrine alkaloids, such as aloperine, cytosine, lehmannine, matrine, oxymartine, oxysophocarpine, sophocar-pine, sophoramine, and sophoridine, the flavonoid kushenol, and the saponin sophoraflavoside. A herbal record lists the following adverse effects of Ku shen: salivation, abnormal gait, dyspnea, tachycardia (71). Matrine upregulates the cell cycle protein E2F-1 and triggers apoptosis via the mitochondrial pathway in K562 cells. The root known as “Ku Shen” which means “bitter root” in Chinese, has been used in Traditional Medicine for two thousand years to treat a variety of conditions including diarrhea, jaundice, and skin rashes, and to kill parasites (1). Novel antitumor activities of Kushen flavonoids in vitro and in vivo. Sophora flavescens has shown anticancer effects in lab studies, but has not been studied for cancer prevention or treatment in humans.Sophora flavescens or Ku Shen, which in Chinese means “bitter root,” is an herb used in Traditional medicine to treat a wide variety of symptoms, with purported effects on the liver, intestinal tract, and skin. There have been three reports of adverse reactions such as nausea, vomiting, dizziness, bradycardia, palpitation, ataxia, pallor, sweating, seizures, and dysphasia. It also demonstrates antiangiogenic effects by inhibiting VEGF and VEGFR-2 (19). Matrine triggers the mitochondrial pathway, in which cytochrome C release induces caspase-9 and -3 activation and subsequently induces apoptosis (2) (3) (10) (21). MSK is revolutionizing the way cancer is understood, diagnosed, and treated. The effects of an ethanol extract of the plant Sophora flavescens Ait. (A), (B) and (C) Growth inhibition assay of SiHa, C33A, Caski and HK-2 was detected by CCK8 assay under different concentrations of Sophora flavescens alkaloid gels (A), matrine (B) and oxymatrine (C) for 48 hours. However, these exhibited side effects, toxicity and low stability toward oxygen and water (Kim & Uyama, 2005). Lab and animal studies have shown that some compounds can kill cancer cells and help fight certain viruses. The drug administration was started from 1 h after the SCI operation and was continued for 31 days. P-glycoprotein (Pgp) does not affect the cytotoxicity of flavonoids from. Oxymatrine, an isolated extract from traditional Chinese herb Sophora Flavescens Ait, has been traditionally used for therapy of anti-hepatitis B virus, anti-inflammation and anti-anaphylaxis. Memorial Sloan Kettering does not record specific website user information and does not contact users of this website. In this post, we will discuss the benefits of ku shen, its caveats, and where to buy ku shen. on cardiac arrhythmias induced by coronary artery ligation in rats, and by aconitine infusion in mice, were studied. Matrine inhibits the activity of translation factor eIF4E through dephosphorylation of 4E-BP1 in gastric MKN45 cells. Certificate of Analysis Patients with hormone-sensitive cancers should avoid this product. But it is not known if these side effects were caused by phellodendron or some other factor. Matrine inhibits proliferation and induces apoptosis of pancreatic cancer cells in vitro and in vivo. In larger doses, nervous system stimulation with … Sophora flavescens extract does not decrease the anti-tumor activity of cisplatin showing that it can selectively inhibit side effects of anticancer drugs preserving beneficial effort. Other flavonoids such as kuraninone and sophoraflavonone are also thought to be biologically active and may have vasodilatory and antiviral effects (5) (6) (7). Evaluation of oriental medicinal herbs for estrogenic and antiproliferative activities. Estrogenic and anticarcinogenic properties of kurarinone, a lavandulyl flavanone from the roots of. Side Effects & Safety When taken by mouth: There isn't enough reliable information to know if cnidium is safe. Special Precautions & Warnings: Therefore, it is essential to identify novel compounds with antiproliferative and pro-apoptotic activities that can be used in targeted therapy against NSCLC. Sophora Root (Ku Shen) is rated 5.0 out of 5 by 1. Side Effects & Safety When taken by mouth: Peony is POSSIBLY SAFE when used by mouth in appropriate amounts, short-term. Users of this Web site should not rely on information provided on this Web site for their own health problems. Ku Shen is effective alone or in the context of a formula. et al. Contents: Basics Of Sophora flavescens. Toxic effects from use of the root may include nausea, dizziness, vomiting, constipation, spasms, disturbance of speech, irregular breathing, respiratory failure and death. Am J Chin Med. Sophora flavescens may act like an estrogen in the body. Can Iron Infusion Cause Arthritis To Flare Up, Tripterygium wilfordii - Side Effects of Drugs. Ku shen (sophora flavescens) is a root with powerful effects on cancer, metabolic diseases, neurological disorders and more.. Matrine induces apoptosis of human multiple myeloma cells via activation of the mitochondrial pathway. A randomized controlled trial of kurorinone versus interferon-alpha2a treatment in patients with chronic hepatitis B. Anticancer effects of the chinese medicine matrine on murine hepatocellular carcinoma cells. This Web site — Information About Herbs, Botanicals and Other Products — is for general health information only. In using this website you agree that neither Memorial Sloan Kettering nor any other party is or will be liable or otherwise responsible for any decision made or any action taken or any action not taken due to your use of any information presented at this website. To investigate the effects of S. flavescens extract in SCI mice, S. flavescens extract (500 mg/kg/day), or vehicle solution was orally administered to SCI mice. Benefits Of Sophora flavescens Ku Shen (Sophora Flavescens) is used by doctors studying a combination of three Chinese herbs that was nearly as effective as prednisone (20 mg/day) for treating athsma. You are hereby advised to consult with a physician or other professional health-care provider prior to making any decisions, or undertaking any actions or not undertaking any actions related to any health care problem or issue you might have at any time, now or in the future. 2003; 31 (4):563–572. Nowadays, many studies are beginning to focus on deriving tyrosinase inhibitors from natural sources such Sophora flavescens Ait. Potential Side Effects of Sophora Flavescens Extract Matrine Oxymatrine. Ku Shen I was introduced to Ku Shen by my daughter who uses it on my grandson for his eczema. How Sophora Flavescens is effective for various diseases is listed in repertory format. Taking it for a long time may cause liver, kidney, lung or brain damage. S. flavescens flavonoids may promote vasodilation by inhibiting Ca2+ influx through a voltage-gated channel (12). 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